ANALYSIS OF GENETIC ALTERATIONS IN EARLY-STAGE OVARIAN CANCER TYPE (EPITHELIAL OVARIAN CANCER) PROGRESSION
Epithelial ovarian cancer (EOC), a major subtype of ovarian cancer (OC) is a complex disease with significant morbidity and mortality rates worldwide, despite the advances made in treatment modalities. Therefore, it is imperative to understand the underlying molecular mechanisms driving EOC progr...
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| Format: | Abschlussarbeit |
| Sprache: | Englisch |
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AUW
2025
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| Schlagworte: | |
| Online-Zugang: | https://repository.auw.edu.bd/handle/123456789/270 |
| _version_ | 1857448868456693760 |
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| author | Eva, Rahima Akter |
| author_facet | Eva, Rahima Akter |
| author_sort | Eva, Rahima Akter |
| collection | institutional Repository |
| description | Epithelial ovarian cancer (EOC), a major subtype of ovarian cancer (OC) is a
complex disease with significant morbidity and mortality rates worldwide, despite the advances
made in treatment modalities. Therefore, it is imperative to understand the underlying
molecular mechanisms driving EOC progression for improving patient outcomes. This study
explored the intricate relationship between FLG2 mutations, CASP14 expression, and the
progression of EOC. By scrutinizing FLG2 mutations across various age groups, structural
predictions were made to assess their impact on protein function and stability. Expression
profiling of FLG2 and CASP14 revealed correlations between their deficiency and decreased
expression in EOC cases. Computational techniques, including molecular docking and
pathway analysis, were employed to validate these findings and identify therapeutic targets.
The research has shown that FLG2 mutations, which are more common in younger age groups,
are linked with decreased CASP14 expression levels. This suggests that there is a regulatory
relationship between these genes in EOC. The findings propose FLG2 and CASP14 as potential
biomarkers for EOC prognosis and therapeutic targeting. |
| format | Thesis |
| id | 123456789-270 |
| institution | Asian University for Women |
| language | English |
| publishDate | 2025 |
| publisher | AUW |
| record_format | dspace |
| spelling | 123456789-2702026-02-18T06:09:54Z ANALYSIS OF GENETIC ALTERATIONS IN EARLY-STAGE OVARIAN CANCER TYPE (EPITHELIAL OVARIAN CANCER) PROGRESSION Eva, Rahima Akter Ovarian cancer, epithelial ovarian cancer, FLG2 mutations, CASP14 expression, biomarkers, molecular mechanisms Epithelial ovarian cancer (EOC), a major subtype of ovarian cancer (OC) is a complex disease with significant morbidity and mortality rates worldwide, despite the advances made in treatment modalities. Therefore, it is imperative to understand the underlying molecular mechanisms driving EOC progression for improving patient outcomes. This study explored the intricate relationship between FLG2 mutations, CASP14 expression, and the progression of EOC. By scrutinizing FLG2 mutations across various age groups, structural predictions were made to assess their impact on protein function and stability. Expression profiling of FLG2 and CASP14 revealed correlations between their deficiency and decreased expression in EOC cases. Computational techniques, including molecular docking and pathway analysis, were employed to validate these findings and identify therapeutic targets. The research has shown that FLG2 mutations, which are more common in younger age groups, are linked with decreased CASP14 expression levels. This suggests that there is a regulatory relationship between these genes in EOC. The findings propose FLG2 and CASP14 as potential biomarkers for EOC prognosis and therapeutic targeting. 2025-04-30T11:10:24Z 2025-04-30T11:10:24Z 2024-05 Thesis https://repository.auw.edu.bd/handle/123456789/270 en application/pdf AUW |
| spellingShingle | Ovarian cancer, epithelial ovarian cancer, FLG2 mutations, CASP14 expression, biomarkers, molecular mechanisms Eva, Rahima Akter ANALYSIS OF GENETIC ALTERATIONS IN EARLY-STAGE OVARIAN CANCER TYPE (EPITHELIAL OVARIAN CANCER) PROGRESSION |
| title | ANALYSIS OF GENETIC ALTERATIONS IN EARLY-STAGE OVARIAN CANCER TYPE (EPITHELIAL OVARIAN CANCER) PROGRESSION |
| title_full | ANALYSIS OF GENETIC ALTERATIONS IN EARLY-STAGE OVARIAN CANCER TYPE (EPITHELIAL OVARIAN CANCER) PROGRESSION |
| title_fullStr | ANALYSIS OF GENETIC ALTERATIONS IN EARLY-STAGE OVARIAN CANCER TYPE (EPITHELIAL OVARIAN CANCER) PROGRESSION |
| title_full_unstemmed | ANALYSIS OF GENETIC ALTERATIONS IN EARLY-STAGE OVARIAN CANCER TYPE (EPITHELIAL OVARIAN CANCER) PROGRESSION |
| title_short | ANALYSIS OF GENETIC ALTERATIONS IN EARLY-STAGE OVARIAN CANCER TYPE (EPITHELIAL OVARIAN CANCER) PROGRESSION |
| title_sort | analysis of genetic alterations in early stage ovarian cancer type epithelial ovarian cancer progression |
| topic | Ovarian cancer, epithelial ovarian cancer, FLG2 mutations, CASP14 expression, biomarkers, molecular mechanisms |
| url | https://repository.auw.edu.bd/handle/123456789/270 |
| work_keys_str_mv | AT evarahimaakter analysisofgeneticalterationsinearlystageovariancancertypeepithelialovariancancerprogression |