| 总结: | The Mayaro virus (MAYV), an arbovirus within the Alphavirus genus, is a significant public
health concern in tropical regions, particularly in Latin America. This study explores the codon
usage patterns of MAYV to uncover its adaptive strategies, host interactions, and evolutionary
dynamics. By analyzing 64 complete MAYV genome sequences, this research reveals a striking
alignment between the virus's codon usage and the human tRNA pool, indicating a strong
adaptation to the host's translational machinery. The Codon Adaptation Index (CAI) value of
0.72914 and the low Similarity Index (SiD) underscore the virus's optimization for efficient
protein synthesis in human cells. Nucleotide composition and relative dinucleotide abundance
analyses highlight key preferences, such as the over-representation of CpU and UpG
dinucleotides and the under-representation of CpG, which may serve as an immune evasion
strategy. The GC3-ENC and neutrality plot analyses suggest that translational selection pressure
plays a more significant role than compositional constraints in shaping MAYV's codon usage
patterns. This study provides crucial insights into the evolutionary dynamics of MAYV and its
adaptation to human hosts. These findings contribute to the understanding of viral genomics and
offer transformative solutions for combating MAYV.
|
|---|