| Тойм: | lncRNAs, or long non-coding RNAs, have become significant regulators of viral infection and
the antiviral response. The purpose of the current study was to examine how the Dengue Virus
(DENV) infection affects lncRNAs. The differentially expressed long noncoding RNA genes
were discovered by studying a transcriptome dataset of DENV-infected cells at several periods.
The research identified 387 downregulated genes and a total of 944 upregulated genes, of which
50 lncRNA genes were downregulated and 39 were upregulated. Seven RNA-binding proteins
were discovered to interact with these lncRNA genes, and these proteins are crucial for both viral
replication and the host immune response. The findings of this study suggest that in DENV
infection, dysregulated lncRNAs play a critical role in viral growth, and immunological
response, eventually dictating the course of the disease. The significance of lncRNAs in the
setting of viral infection is highlighted by the findings, which may have a substantial impact on
the creation of novel treatment approaches for DENV infection. The research adds to the
expanding body of knowledge on non-coding RNAs' function in viral pathogenesis and lays the
groundwork for future investigations into the specific processes driving lncRNA-mediated
control of dengue virus infection.
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