“Targeting Porphyromonas gingivalis in Oral and Esophageal Cancer: A Bioinformatic and Medicinal Plant-Based Approach”
Oral cancer remains a significant global health challenge, ranking as the sixth most common cancer worldwide, with over 90% of cases being oral squamous cell carcinoma (OSCC). Porphyromonas gingivalis, a Gram-negative anaerobic bacterium and key pathogen in periodontitis, contributes to cancer de...
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| Format: | Thesis |
| Language: | English |
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AUW
2025
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| Online Access: | https://repository.auw.edu.bd/handle/123456789/532 |
| _version_ | 1857448924226256896 |
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| author | Anika, Ayesha |
| author_facet | Anika, Ayesha |
| author_sort | Anika, Ayesha |
| collection | institutional Repository |
| description | Oral cancer remains a significant global health challenge, ranking as the sixth most common
cancer worldwide, with over 90% of cases being oral squamous cell carcinoma (OSCC).
Porphyromonas gingivalis, a Gram-negative anaerobic bacterium and key pathogen in
periodontitis, contributes to cancer development by evading immune responses, inducing chronic
inflammation, and promoting apoptosis of gingival epithelial cells. It has also been linked to
systemic conditions, including cardiovascular disease and gastrointestinal cancers. This study
aimed to identify common proteins dysregulated by P. gingivalis infection in oral and esophageal
cancers, to explore the antimicrobial resistance (AMR) and essential gene mechanisms in P.
gingivalis, and to target antibiotic-resistant hub genes using medicinal plant-based drug
discovery approaches.
Using in silico methods, AMR and essential genes were identified from P. gingivalis strains W83
and ATCC 33277. Pathway enrichment and protein-protein interaction analyses highlighted these
genes' relevance in cancer progression.OSCC & ESCC datasets were analyzed against P.
gingivalis. Finally, molecular docking was conducted & Rutin demonstrated the strongest
binding affinity, suggesting its potential as a therapeutic lead. This integrative bioinformatic and
natural compound-based approach offers promising avenues for targeting P. gingivalis-driven
cancers and overcoming its antibiotic resistance. |
| format | Thesis |
| id | 123456789-532 |
| institution | Asian University for Women |
| language | English |
| publishDate | 2025 |
| publisher | AUW |
| record_format | dspace |
| spelling | 123456789-5322026-02-18T06:09:51Z “Targeting Porphyromonas gingivalis in Oral and Esophageal Cancer: A Bioinformatic and Medicinal Plant-Based Approach” Dept. of Bioinformatics and Biotechnology Anika, Ayesha Oral cancer remains a significant global health challenge, ranking as the sixth most common cancer worldwide, with over 90% of cases being oral squamous cell carcinoma (OSCC). Porphyromonas gingivalis, a Gram-negative anaerobic bacterium and key pathogen in periodontitis, contributes to cancer development by evading immune responses, inducing chronic inflammation, and promoting apoptosis of gingival epithelial cells. It has also been linked to systemic conditions, including cardiovascular disease and gastrointestinal cancers. This study aimed to identify common proteins dysregulated by P. gingivalis infection in oral and esophageal cancers, to explore the antimicrobial resistance (AMR) and essential gene mechanisms in P. gingivalis, and to target antibiotic-resistant hub genes using medicinal plant-based drug discovery approaches. Using in silico methods, AMR and essential genes were identified from P. gingivalis strains W83 and ATCC 33277. Pathway enrichment and protein-protein interaction analyses highlighted these genes' relevance in cancer progression.OSCC & ESCC datasets were analyzed against P. gingivalis. Finally, molecular docking was conducted & Rutin demonstrated the strongest binding affinity, suggesting its potential as a therapeutic lead. This integrative bioinformatic and natural compound-based approach offers promising avenues for targeting P. gingivalis-driven cancers and overcoming its antibiotic resistance. 2025-07-13T06:38:11Z 2025-07-13T06:38:11Z 2025-04 Thesis https://repository.auw.edu.bd/handle/123456789/532 en application/pdf AUW |
| spellingShingle | Anika, Ayesha “Targeting Porphyromonas gingivalis in Oral and Esophageal Cancer: A Bioinformatic and Medicinal Plant-Based Approach” |
| title | “Targeting Porphyromonas gingivalis in Oral and Esophageal Cancer: A Bioinformatic and Medicinal Plant-Based Approach” |
| title_full | “Targeting Porphyromonas gingivalis in Oral and Esophageal Cancer: A Bioinformatic and Medicinal Plant-Based Approach” |
| title_fullStr | “Targeting Porphyromonas gingivalis in Oral and Esophageal Cancer: A Bioinformatic and Medicinal Plant-Based Approach” |
| title_full_unstemmed | “Targeting Porphyromonas gingivalis in Oral and Esophageal Cancer: A Bioinformatic and Medicinal Plant-Based Approach” |
| title_short | “Targeting Porphyromonas gingivalis in Oral and Esophageal Cancer: A Bioinformatic and Medicinal Plant-Based Approach” |
| title_sort | targeting porphyromonas gingivalis in oral and esophageal cancer a bioinformatic and medicinal plant based approach |
| url | https://repository.auw.edu.bd/handle/123456789/532 |
| work_keys_str_mv | AT anikaayesha targetingporphyromonasgingivalisinoralandesophagealcancerabioinformaticandmedicinalplantbasedapproach AT anikaayesha deptofbioinformaticsandbiotechnology |