Leveraging Codon Usage Dynamics to Unravel Host Adaptation Mechanisms in Human Sapovirus
Acute gastroenteritis (AGE) is a major public health concern contributing to over 2.5 million annual deaths globally. Sapovirus infection cases have gained prominence in recent outbreaks of gastroenteritis. Given the absence of targeted therapies or vaccines against this virus, understanding its...
| Kaituhi matua: | |
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| Hōputu: | Tuhinga whakapae |
| Reo: | Ingarihi |
| I whakaputaina: |
AUW
2025
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| Urunga tuihono: | https://repository.auw.edu.bd/handle/123456789/544 |
| _version_ | 1857448879317843968 |
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| author | Hossain Tani, Tazneen |
| author_facet | Hossain Tani, Tazneen |
| author_sort | Hossain Tani, Tazneen |
| collection | institutional Repository |
| description | Acute gastroenteritis (AGE) is a major public health concern contributing to over 2.5 million
annual deaths globally. Sapovirus infection cases have gained prominence in recent outbreaks of
gastroenteritis. Given the absence of targeted therapies or vaccines against this virus,
understanding its molecular evolution and host adaptation is crucial. In this study, we analyzed
98 complete Sapovirus genomes to investigate nucleotide composition, codon usage bias, and
adaptation to the human host. Our results revealed notable codon preferences and a codon bias
moderated by both host selection pressure and compositional constraint. Dinucleotide analysis
showed over-representation of UpG and CpA, and under-representation of immunogenic motifs
like CpG and UpA. The findings of this study underscore the evolutionary pressures shaping
Sapovirus genomes and provide a basis for codon profiling for future studies to use in the
development of synthetic attenuated vaccines using SAVE technology. |
| format | Thesis |
| id | 123456789-544 |
| institution | Asian University for Women |
| language | English |
| publishDate | 2025 |
| publisher | AUW |
| record_format | dspace |
| spelling | 123456789-5442026-02-18T06:09:55Z Leveraging Codon Usage Dynamics to Unravel Host Adaptation Mechanisms in Human Sapovirus Hossain Tani, Tazneen Acute gastroenteritis (AGE) is a major public health concern contributing to over 2.5 million annual deaths globally. Sapovirus infection cases have gained prominence in recent outbreaks of gastroenteritis. Given the absence of targeted therapies or vaccines against this virus, understanding its molecular evolution and host adaptation is crucial. In this study, we analyzed 98 complete Sapovirus genomes to investigate nucleotide composition, codon usage bias, and adaptation to the human host. Our results revealed notable codon preferences and a codon bias moderated by both host selection pressure and compositional constraint. Dinucleotide analysis showed over-representation of UpG and CpA, and under-representation of immunogenic motifs like CpG and UpA. The findings of this study underscore the evolutionary pressures shaping Sapovirus genomes and provide a basis for codon profiling for future studies to use in the development of synthetic attenuated vaccines using SAVE technology. 2025-07-13T07:10:47Z 2025-07-13T07:10:47Z 2025-04 Thesis https://repository.auw.edu.bd/handle/123456789/544 en application/pdf AUW |
| spellingShingle | Hossain Tani, Tazneen Leveraging Codon Usage Dynamics to Unravel Host Adaptation Mechanisms in Human Sapovirus |
| title | Leveraging Codon Usage Dynamics to Unravel Host Adaptation Mechanisms in Human Sapovirus |
| title_full | Leveraging Codon Usage Dynamics to Unravel Host Adaptation Mechanisms in Human Sapovirus |
| title_fullStr | Leveraging Codon Usage Dynamics to Unravel Host Adaptation Mechanisms in Human Sapovirus |
| title_full_unstemmed | Leveraging Codon Usage Dynamics to Unravel Host Adaptation Mechanisms in Human Sapovirus |
| title_short | Leveraging Codon Usage Dynamics to Unravel Host Adaptation Mechanisms in Human Sapovirus |
| title_sort | leveraging codon usage dynamics to unravel host adaptation mechanisms in human sapovirus |
| url | https://repository.auw.edu.bd/handle/123456789/544 |
| work_keys_str_mv | AT hossaintanitazneen leveragingcodonusagedynamicstounravelhostadaptationmechanismsinhumansapovirus |