Exploring Bioactive Compounds in Traditionally Fermented Bamboo Shoots for Anti-Klebsiella pneumoniae Activity and Host Digestive System Modulation
This study investigated the phytochemical composition and potential health benefits of traditionally fermented bamboo shoots (Bambusa bambos), with a dual focus on their antimicrobial activity against multidrug-resistant (MDR) Klebsiella pneumoniae and their potential to modulate human biological...
| المؤلف الرئيسي: | |
|---|---|
| التنسيق: | أطروحة |
| اللغة: | الإنجليزية |
| منشور في: |
AUW
2025
|
| الوصول للمادة أونلاين: | https://repository.auw.edu.bd/handle/123456789/545 |
| _version_ | 1857448838988562432 |
|---|---|
| author | Bint Akbar, Yusra |
| author_facet | Bint Akbar, Yusra |
| author_sort | Bint Akbar, Yusra |
| collection | institutional Repository |
| description | This study investigated the phytochemical composition and potential health benefits
of traditionally fermented bamboo shoots (Bambusa bambos), with a dual focus on their
antimicrobial activity against multidrug-resistant (MDR) Klebsiella pneumoniae and their
potential to modulate human biological pathways related to gut and metabolic health. Rooted in
traditional food practices from the Chittagong Hill Tracts of Bangladesh, fermented bamboo
shoots were not only valued for their nutritional properties but also contained bioactive
compounds that might serve therapeutic functions.
Using a combination of traditional brine water fermentation, ethanol extraction, and qualitative
phytochemical screening, several key compounds were identified, including riboflavin, benzoic
acid, oxalic acid, betaine, taxiphyllin, and nicotinic acid. Initial antibacterial assays revealed
modest zones of inhibition, suggesting low but present antimicrobial activity. To explore the
mechanisms behind these effects, molecular docking demonstrated that riboflavin and benzoic
acid strongly interacted with essential bacterial enzymes (ribF and Acs), indicating potential for
metabolic disruption in K. pneumoniae.
Complementary in silico analyses showed that these compounds also interacted with human
proteins involved in immune signaling, antioxidant defense, and metabolic regulation.
Protein–protein interaction networks and pathway enrichment analyses suggested modulation of
key signaling pathways such as PI3K-Akt, Ras, and chemokine cascades—particularly in the
stomach, colon, and liver—highlighting their role in gut barrier integrity, inflammation control,
and systemic immunity.
Overall, the findings suggested that fermented bamboo shoots might act as functional foods
with dual antimicrobial and host-modulatory properties. While their direct antibacterial effects in
vitro were limited, their broader molecular interactions pointed to a promising role in promoting
digestive and immune health, and in complementing strategies to manage antimicrobial
resistance. This study bridged indigenous knowledge and modern science, reinforcing the value
of traditional fermentation in enhancing the nutritional and medicinal value of local foods. |
| format | Thesis |
| id | 123456789-545 |
| institution | Asian University for Women |
| language | English |
| publishDate | 2025 |
| publisher | AUW |
| record_format | dspace |
| spelling | 123456789-5452026-02-18T06:09:54Z Exploring Bioactive Compounds in Traditionally Fermented Bamboo Shoots for Anti-Klebsiella pneumoniae Activity and Host Digestive System Modulation Bint Akbar, Yusra This study investigated the phytochemical composition and potential health benefits of traditionally fermented bamboo shoots (Bambusa bambos), with a dual focus on their antimicrobial activity against multidrug-resistant (MDR) Klebsiella pneumoniae and their potential to modulate human biological pathways related to gut and metabolic health. Rooted in traditional food practices from the Chittagong Hill Tracts of Bangladesh, fermented bamboo shoots were not only valued for their nutritional properties but also contained bioactive compounds that might serve therapeutic functions. Using a combination of traditional brine water fermentation, ethanol extraction, and qualitative phytochemical screening, several key compounds were identified, including riboflavin, benzoic acid, oxalic acid, betaine, taxiphyllin, and nicotinic acid. Initial antibacterial assays revealed modest zones of inhibition, suggesting low but present antimicrobial activity. To explore the mechanisms behind these effects, molecular docking demonstrated that riboflavin and benzoic acid strongly interacted with essential bacterial enzymes (ribF and Acs), indicating potential for metabolic disruption in K. pneumoniae. Complementary in silico analyses showed that these compounds also interacted with human proteins involved in immune signaling, antioxidant defense, and metabolic regulation. Protein–protein interaction networks and pathway enrichment analyses suggested modulation of key signaling pathways such as PI3K-Akt, Ras, and chemokine cascades—particularly in the stomach, colon, and liver—highlighting their role in gut barrier integrity, inflammation control, and systemic immunity. Overall, the findings suggested that fermented bamboo shoots might act as functional foods with dual antimicrobial and host-modulatory properties. While their direct antibacterial effects in vitro were limited, their broader molecular interactions pointed to a promising role in promoting digestive and immune health, and in complementing strategies to manage antimicrobial resistance. This study bridged indigenous knowledge and modern science, reinforcing the value of traditional fermentation in enhancing the nutritional and medicinal value of local foods. 2025-07-13T07:13:55Z 2025-07-13T07:13:55Z 2025-04 Thesis https://repository.auw.edu.bd/handle/123456789/545 en application/pdf AUW |
| spellingShingle | Bint Akbar, Yusra Exploring Bioactive Compounds in Traditionally Fermented Bamboo Shoots for Anti-Klebsiella pneumoniae Activity and Host Digestive System Modulation |
| title | Exploring Bioactive Compounds in Traditionally Fermented Bamboo Shoots for Anti-Klebsiella pneumoniae Activity and Host Digestive System Modulation |
| title_full | Exploring Bioactive Compounds in Traditionally Fermented Bamboo Shoots for Anti-Klebsiella pneumoniae Activity and Host Digestive System Modulation |
| title_fullStr | Exploring Bioactive Compounds in Traditionally Fermented Bamboo Shoots for Anti-Klebsiella pneumoniae Activity and Host Digestive System Modulation |
| title_full_unstemmed | Exploring Bioactive Compounds in Traditionally Fermented Bamboo Shoots for Anti-Klebsiella pneumoniae Activity and Host Digestive System Modulation |
| title_short | Exploring Bioactive Compounds in Traditionally Fermented Bamboo Shoots for Anti-Klebsiella pneumoniae Activity and Host Digestive System Modulation |
| title_sort | exploring bioactive compounds in traditionally fermented bamboo shoots for anti klebsiella pneumoniae activity and host digestive system modulation |
| url | https://repository.auw.edu.bd/handle/123456789/545 |
| work_keys_str_mv | AT bintakbaryusra exploringbioactivecompoundsintraditionallyfermentedbambooshootsforantiklebsiellapneumoniaeactivityandhostdigestivesystemmodulation |