Comparative evolutionary genomics of Corynebacterium with special reference to codon and amino acid usage diversities
The present study has been aimed to the com- parative analysis of high GC composition containing Corynebacterium genomes and their evolutionary study by exploring codon and amino acid usage patterns. Phyloge- netic study by MLSA approach, indel analysis and BLAST matrix differentiated Cor...
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| Formato: | Artigo |
| Idioma: | inglês |
| Publicado em: |
CrossMark
2025
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| Assuntos: | |
| Acesso em linha: | https://repository.auw.edu.bd/handle/123456789/751 |
| _version_ | 1857448840236367872 |
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| author | Roy, Ayan |
| author_facet | Roy, Ayan |
| author_sort | Roy, Ayan |
| collection | institutional Repository |
| description | The present study has been aimed to the com-
parative analysis of high GC composition containing
Corynebacterium genomes and their evolutionary study by
exploring codon and amino acid usage patterns. Phyloge-
netic study by MLSA approach, indel analysis and BLAST
matrix differentiated Corynebacterium species in pathogenic
and non-pathogenic clusters. Correspondence analysis on
synonymous codon usage reveals that, gene length, optimal
codon frequencies and tRNA abundance affect the gene
expression of Corynebacterium. Most of the optimal codons
as well as translationally optimal codons are C ending i.e.
RNY (R-purine, N-any nucleotide base, and Y-pyrimidine)
and reveal translational selection pressure on codon bias of
Corynebacterium. Amino acid usage is affected by hydro-
phobicity, aromaticity, protein energy cost, etc. Highly
expressed genes followed the cost minimization hypoth-
esis and are less diverged at their synonymous positions of
codons. Functional analysis of core genes shows significant
difference in pathogenic and non-pathogenic Corynebac-
terium. The study reveals close relationship between non-
pathogenic and opportunistic pathogenic Corynebaterium
as well as between molecular evolution and survival niches
of the organism. |
| format | Article |
| id | 123456789-751 |
| institution | Asian University for Women |
| language | English |
| publishDate | 2025 |
| publisher | CrossMark |
| record_format | dspace |
| spelling | 123456789-7512026-02-18T06:15:28Z Comparative evolutionary genomics of Corynebacterium with special reference to codon and amino acid usage diversities Roy, Ayan Correspondence analysis · Indel · MLSA · Synonymous nucleotide substitution · Translational selection The present study has been aimed to the com- parative analysis of high GC composition containing Corynebacterium genomes and their evolutionary study by exploring codon and amino acid usage patterns. Phyloge- netic study by MLSA approach, indel analysis and BLAST matrix differentiated Corynebacterium species in pathogenic and non-pathogenic clusters. Correspondence analysis on synonymous codon usage reveals that, gene length, optimal codon frequencies and tRNA abundance affect the gene expression of Corynebacterium. Most of the optimal codons as well as translationally optimal codons are C ending i.e. RNY (R-purine, N-any nucleotide base, and Y-pyrimidine) and reveal translational selection pressure on codon bias of Corynebacterium. Amino acid usage is affected by hydro- phobicity, aromaticity, protein energy cost, etc. Highly expressed genes followed the cost minimization hypoth- esis and are less diverged at their synonymous positions of codons. Functional analysis of core genes shows significant difference in pathogenic and non-pathogenic Corynebac- terium. The study reveals close relationship between non- pathogenic and opportunistic pathogenic Corynebaterium as well as between molecular evolution and survival niches of the organism. 2025-07-22T05:58:40Z 2025-07-22T05:58:40Z 2018 Article https://repository.auw.edu.bd/handle/123456789/751 en application/pdf CrossMark |
| spellingShingle | Correspondence analysis · Indel · MLSA · Synonymous nucleotide substitution · Translational selection Roy, Ayan Comparative evolutionary genomics of Corynebacterium with special reference to codon and amino acid usage diversities |
| title | Comparative evolutionary genomics of Corynebacterium with special reference to codon and amino acid usage diversities |
| title_full | Comparative evolutionary genomics of Corynebacterium with special reference to codon and amino acid usage diversities |
| title_fullStr | Comparative evolutionary genomics of Corynebacterium with special reference to codon and amino acid usage diversities |
| title_full_unstemmed | Comparative evolutionary genomics of Corynebacterium with special reference to codon and amino acid usage diversities |
| title_short | Comparative evolutionary genomics of Corynebacterium with special reference to codon and amino acid usage diversities |
| title_sort | comparative evolutionary genomics of corynebacterium with special reference to codon and amino acid usage diversities |
| topic | Correspondence analysis · Indel · MLSA · Synonymous nucleotide substitution · Translational selection |
| url | https://repository.auw.edu.bd/handle/123456789/751 |
| work_keys_str_mv | AT royayan comparativeevolutionarygenomicsofcorynebacteriumwithspecialreferencetocodonandaminoacidusagediversities |