Evolutionary perspectives and adaptation dynamics of human seasonal influenza viruses from 2009 to 2019:an insight from codon usage
The annually recurrent seasonal influenza viruses, namely, influenza A viruses (H1N1/pdm2009 and H3N2) and influenza B viruses, contribute substantially to human disease burden. Elucidation of host adaptation, population dynamics and evolutionary patterns of these viruses contribute to better con...
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ELSEVIER
2025
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| Mynediad Ar-lein: | https://repository.auw.edu.bd/handle/123456789/776 |
| _version_ | 1857448840894873600 |
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| author | Roy, Ayan |
| author_facet | Roy, Ayan |
| author_sort | Roy, Ayan |
| collection | institutional Repository |
| description | The annually recurrent seasonal influenza viruses, namely, influenza A viruses
(H1N1/pdm2009 and H3N2) and influenza B viruses, contribute substantially to
human disease burden. Elucidation of host adaptation, population dynamics and
evolutionary patterns of these viruses contribute to better control of current epidemic
situation and bolster efforts towards pandemic preparedness. Present study has been
addressed at unraveling the signatures of codon usage and dinucleotide distribution of
these seasonal influenza viruses associating with their fitness and ongoing adaptive
evolution in human population. Thorough analysis of codon usage adaptation revealed
that H3N2 has been exhibited best adapted to human cellular system, which correlate
with its highest epidemic intensity as compared with the other seasonal influenza
viruses. CpG dinucleotide was found to be strongly avoided among the seasonal
influenza viruses with more restraint among influenza B viruses than influenza A
viruses, and might be accounted to the strategy of the viral pathogens in evading
human immune signals. Dynamic scenes of ongoing evolution in codon usage and
elimination of CpG motif among the viruses, which correlate with their distinct host
adaption state, signifying the marked impact of selective force operational on the viral
genomes, aimed at proficient circulation, enhanced fitness and successful infective manifestations in humans. |
| format | Article |
| id | 123456789-776 |
| institution | Asian University for Women |
| language | English |
| publishDate | 2025 |
| publisher | ELSEVIER |
| record_format | dspace |
| spelling | 123456789-7762026-02-18T06:15:11Z Evolutionary perspectives and adaptation dynamics of human seasonal influenza viruses from 2009 to 2019:an insight from codon usage Roy, Ayan Seasonal influenza viruses; Codon usage; Evolutionary analysis; Codon adaptation index; Host adaptation; CpG dinucleotide. The annually recurrent seasonal influenza viruses, namely, influenza A viruses (H1N1/pdm2009 and H3N2) and influenza B viruses, contribute substantially to human disease burden. Elucidation of host adaptation, population dynamics and evolutionary patterns of these viruses contribute to better control of current epidemic situation and bolster efforts towards pandemic preparedness. Present study has been addressed at unraveling the signatures of codon usage and dinucleotide distribution of these seasonal influenza viruses associating with their fitness and ongoing adaptive evolution in human population. Thorough analysis of codon usage adaptation revealed that H3N2 has been exhibited best adapted to human cellular system, which correlate with its highest epidemic intensity as compared with the other seasonal influenza viruses. CpG dinucleotide was found to be strongly avoided among the seasonal influenza viruses with more restraint among influenza B viruses than influenza A viruses, and might be accounted to the strategy of the viral pathogens in evading human immune signals. Dynamic scenes of ongoing evolution in codon usage and elimination of CpG motif among the viruses, which correlate with their distinct host adaption state, signifying the marked impact of selective force operational on the viral genomes, aimed at proficient circulation, enhanced fitness and successful infective manifestations in humans. 2025-07-24T07:24:28Z 2025-07-24T07:24:28Z 2021 Article https://repository.auw.edu.bd/handle/123456789/776 en application/pdf ELSEVIER |
| spellingShingle | Seasonal influenza viruses; Codon usage; Evolutionary analysis; Codon adaptation index; Host adaptation; CpG dinucleotide. Roy, Ayan Evolutionary perspectives and adaptation dynamics of human seasonal influenza viruses from 2009 to 2019:an insight from codon usage |
| title | Evolutionary perspectives and adaptation dynamics of human seasonal influenza viruses from 2009 to 2019:an insight from codon usage |
| title_full | Evolutionary perspectives and adaptation dynamics of human seasonal influenza viruses from 2009 to 2019:an insight from codon usage |
| title_fullStr | Evolutionary perspectives and adaptation dynamics of human seasonal influenza viruses from 2009 to 2019:an insight from codon usage |
| title_full_unstemmed | Evolutionary perspectives and adaptation dynamics of human seasonal influenza viruses from 2009 to 2019:an insight from codon usage |
| title_short | Evolutionary perspectives and adaptation dynamics of human seasonal influenza viruses from 2009 to 2019:an insight from codon usage |
| title_sort | evolutionary perspectives and adaptation dynamics of human seasonal influenza viruses from 2009 to 2019 an insight from codon usage |
| topic | Seasonal influenza viruses; Codon usage; Evolutionary analysis; Codon adaptation index; Host adaptation; CpG dinucleotide. |
| url | https://repository.auw.edu.bd/handle/123456789/776 |
| work_keys_str_mv | AT royayan evolutionaryperspectivesandadaptationdynamicsofhumanseasonalinfluenzavirusesfrom2009to2019aninsightfromcodonusage |