Synthesis of Carvacrol Derivatives as Potential New Anticancer Agent against Lung Cancer
Lung cancer remains a major public health concern among all cancer diseases due to the toxicity and side-effects of the available commercially synthesized drugs. Natural product-derived synthesized anticancer drugs are now of promising interest to fight against cancer death. Carvacrol is a major...
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| Natura: | Articolo |
| Lingua: | inglese |
| Pubblicazione: |
MDPI
2025
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| Soggetti: | |
| Accesso online: | https://repository.auw.edu.bd/handle/123456789/780 |
| _version_ | 1857448963757572096 |
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| author | Roy, Ayan |
| author_facet | Roy, Ayan |
| author_sort | Roy, Ayan |
| collection | institutional Repository |
| description | Lung cancer remains a major public health concern among all cancer diseases due to the
toxicity and side-effects of the available commercially synthesized drugs. Natural product-derived
synthesized anticancer drugs are now of promising interest to fight against cancer death. Carvacrol
is a major component of most essential oil-bearing plants with potential pharmacological activity,
especially against various cancer cell lines. Among the other organometallic compounds, copper
complexes have been reported to be effective anticancer agents against various cancer cell lines,
especially lung and leukemia cancers, due to the nontoxic nature of copper in normal cells since
it is an endogenic metal. In this study, we synthesized three carvacrol derivatives, i.e., carvacrol
aldehyde, Schiff base, and copper–Schiff base complex, through an established synthesis protocol
and characterized the synthesized product using various spectroscopic techniques. The synthesized
derivatives were evaluated for in vitro cytotoxic activity against different cancer cell lines, including
human lung cancer (A549) and human fibroblast (BALB-3T3). Our findings showed that the copper–
Schiff base complex derived from carvacrol inhibited the proliferation and migration of the A549 cell
lines in a dose-dependent manner. This activity might be due to the inhibition of cell proliferation
and migration at the G2/M cell-cycle phase, as well as apoptosis, possibly through the activation
of the mitochondrial apoptotic pathway. To our knowledge, this is the first report on the activity
of the copper–Schiff base complex of carvacrol against A549 cell lines. Our result highlights that a
new synthesized copper complex from carvacrol could be a novel potential drug in the treatment of
lung cancer. |
| format | Article |
| id | 123456789-780 |
| institution | Asian University for Women |
| language | English |
| publishDate | 2025 |
| publisher | MDPI |
| record_format | dspace |
| spelling | 123456789-7802026-02-18T06:15:07Z Synthesis of Carvacrol Derivatives as Potential New Anticancer Agent against Lung Cancer Roy, Ayan apoptosis; carvacrol; carvacrol aldehyde; copper–Schiff base complex; lung cancer; A549 cells Lung cancer remains a major public health concern among all cancer diseases due to the toxicity and side-effects of the available commercially synthesized drugs. Natural product-derived synthesized anticancer drugs are now of promising interest to fight against cancer death. Carvacrol is a major component of most essential oil-bearing plants with potential pharmacological activity, especially against various cancer cell lines. Among the other organometallic compounds, copper complexes have been reported to be effective anticancer agents against various cancer cell lines, especially lung and leukemia cancers, due to the nontoxic nature of copper in normal cells since it is an endogenic metal. In this study, we synthesized three carvacrol derivatives, i.e., carvacrol aldehyde, Schiff base, and copper–Schiff base complex, through an established synthesis protocol and characterized the synthesized product using various spectroscopic techniques. The synthesized derivatives were evaluated for in vitro cytotoxic activity against different cancer cell lines, including human lung cancer (A549) and human fibroblast (BALB-3T3). Our findings showed that the copper– Schiff base complex derived from carvacrol inhibited the proliferation and migration of the A549 cell lines in a dose-dependent manner. This activity might be due to the inhibition of cell proliferation and migration at the G2/M cell-cycle phase, as well as apoptosis, possibly through the activation of the mitochondrial apoptotic pathway. To our knowledge, this is the first report on the activity of the copper–Schiff base complex of carvacrol against A549 cell lines. Our result highlights that a new synthesized copper complex from carvacrol could be a novel potential drug in the treatment of lung cancer. 2025-07-24T07:43:39Z 2025-07-24T07:43:39Z 2022 Article https://repository.auw.edu.bd/handle/123456789/780 en application/pdf MDPI |
| spellingShingle | apoptosis; carvacrol; carvacrol aldehyde; copper–Schiff base complex; lung cancer; A549 cells Roy, Ayan Synthesis of Carvacrol Derivatives as Potential New Anticancer Agent against Lung Cancer |
| title | Synthesis of Carvacrol Derivatives as Potential New Anticancer Agent against Lung Cancer |
| title_full | Synthesis of Carvacrol Derivatives as Potential New Anticancer Agent against Lung Cancer |
| title_fullStr | Synthesis of Carvacrol Derivatives as Potential New Anticancer Agent against Lung Cancer |
| title_full_unstemmed | Synthesis of Carvacrol Derivatives as Potential New Anticancer Agent against Lung Cancer |
| title_short | Synthesis of Carvacrol Derivatives as Potential New Anticancer Agent against Lung Cancer |
| title_sort | synthesis of carvacrol derivatives as potential new anticancer agent against lung cancer |
| topic | apoptosis; carvacrol; carvacrol aldehyde; copper–Schiff base complex; lung cancer; A549 cells |
| url | https://repository.auw.edu.bd/handle/123456789/780 |
| work_keys_str_mv | AT royayan synthesisofcarvacrolderivativesaspotentialnewanticanceragentagainstlungcancer |