Adaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats
Bamboo rats (Rhizomys pruinosus) are among the few mammals that lives on a bamboo-based diet which is mainly composed of lignocellulose. However, the mechanisms of adaptation of their gut microbiome and metabolic systems in the degradation of lignocellulose are largely unknown. Here, we conducted...
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| Formatua: | Artikulua |
| Hizkuntza: | ingelesa |
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ISME
2025
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| Sarrera elektronikoa: | https://repository.auw.edu.bd/handle/123456789/783 |
| _version_ | 1857448963858235392 |
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| author | Roy, Ayan |
| author_facet | Roy, Ayan |
| author_sort | Roy, Ayan |
| collection | institutional Repository |
| description | Bamboo rats (Rhizomys pruinosus) are among the few mammals that lives on a bamboo-based diet which is mainly composed of
lignocellulose. However, the mechanisms of adaptation of their gut microbiome and metabolic systems in the degradation of
lignocellulose are largely unknown. Here, we conducted a multi-omics analysis on bamboo rats to investigate the interaction
between their gut microbiomes and metabolic systems in the pre- and post-weaning periods, and observed significant
relationships between dietary types, gut microbiome, serum metabolome and host gene expression. For comparison, published gut
microbial data from the famous bamboo-eating giant panda (Ailuropoda melanoleuca) were also used for analysis. We found that
the adaptation of the gut microbiome of the bamboo rat to a lignocellulose diet is related to a member switch in the order
Bacteroidales from family Bacteroidaceae to family Muribaculaceae, while for the famous bamboo-eating giant panda, several
aerobes and facultative anaerobes increase after weaning. The conversion of bacteria with an increased relative abundance in
bamboo rats after weaning enriched diverse carbohydrate-active enzymes (CAZymes) associated with lignocellulose degradation
and functionally enhanced the biosynthesis of amino acids and B vitamins. Meanwhile, the circulating concentration of short-chain
fatty acids (SCFAs) derived metabolites and the metabolic capacity of linoleic acid in the host were significantly elevated. Our
findings suggest that fatty acid metabolism, including linoleic acid and SCFAs, are the main energy sources for bamboo rats in
response to the low-nutrient bamboo diet. |
| format | Article |
| id | 123456789-783 |
| institution | Asian University for Women |
| language | English |
| publishDate | 2025 |
| publisher | ISME |
| record_format | dspace |
| spelling | 123456789-7832026-02-18T06:15:18Z Adaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats Roy, Ayan Bamboo rats (Rhizomys pruinosus) are among the few mammals that lives on a bamboo-based diet which is mainly composed of lignocellulose. However, the mechanisms of adaptation of their gut microbiome and metabolic systems in the degradation of lignocellulose are largely unknown. Here, we conducted a multi-omics analysis on bamboo rats to investigate the interaction between their gut microbiomes and metabolic systems in the pre- and post-weaning periods, and observed significant relationships between dietary types, gut microbiome, serum metabolome and host gene expression. For comparison, published gut microbial data from the famous bamboo-eating giant panda (Ailuropoda melanoleuca) were also used for analysis. We found that the adaptation of the gut microbiome of the bamboo rat to a lignocellulose diet is related to a member switch in the order Bacteroidales from family Bacteroidaceae to family Muribaculaceae, while for the famous bamboo-eating giant panda, several aerobes and facultative anaerobes increase after weaning. The conversion of bacteria with an increased relative abundance in bamboo rats after weaning enriched diverse carbohydrate-active enzymes (CAZymes) associated with lignocellulose degradation and functionally enhanced the biosynthesis of amino acids and B vitamins. Meanwhile, the circulating concentration of short-chain fatty acids (SCFAs) derived metabolites and the metabolic capacity of linoleic acid in the host were significantly elevated. Our findings suggest that fatty acid metabolism, including linoleic acid and SCFAs, are the main energy sources for bamboo rats in response to the low-nutrient bamboo diet. 2025-07-24T07:59:05Z 2025-07-24T07:59:05Z 2022 Article https://repository.auw.edu.bd/handle/123456789/783 en application/pdf ISME |
| spellingShingle | Roy, Ayan Adaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats |
| title | Adaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats |
| title_full | Adaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats |
| title_fullStr | Adaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats |
| title_full_unstemmed | Adaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats |
| title_short | Adaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats |
| title_sort | adaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats |
| url | https://repository.auw.edu.bd/handle/123456789/783 |
| work_keys_str_mv | AT royayan adaptationofgutmicrobiomeandhostmetabolicsystemstolignocellulosicdegradationinbamboorats |