South African Journal of Botany
Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic dysfunction characterized by hyperglycemia. T2DM is a growing global epidemic with diffuse complications, including a high mortality rate. High blood sugar can be lowered by impeding the activities of pancreatic a-amylase and intestinal a-gluc...
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| Formatua: | Artikulua |
| Hizkuntza: | ingelesa |
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ELSEVIER
2025
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| Sarrera elektronikoa: | https://repository.auw.edu.bd/handle/123456789/833 |
| _version_ | 1857448841115074560 |
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| author | Roy, Ayan |
| author_facet | Roy, Ayan |
| author_sort | Roy, Ayan |
| collection | institutional Repository |
| description | Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic dysfunction characterized by hyperglycemia. T2DM is
a growing global epidemic with diffuse complications, including a high mortality rate. High blood sugar can
be lowered by impeding the activities of pancreatic a-amylase and intestinal a-glucosidase enzymes.
Although there are a number of orthodox medications used in the management of hyperglycemia, medicinal
plants remain a veritable option in many cultures of the world owing to their overall efficacy and affordabil-
ity. This study was designed to investigate the hypoglycemic potential of Syzygium cordatum leaf extract frac-
tions in the retardation of pancreatic a-amylase and intestinal a-glucosidase enzymes in vitro. The bioactive
components of the active fractions were identified using the Gas Chromatography-Mass Spectrometry (GC-
MS) and their potential hypoglycemic properties were assessed using the molecular in silico modelling
approach. The in vitro a-amylase and a-glucosidase inhibitory activities of S. cordatum revealed that the
organic solvent fractions retarded the digestive enzymes considerably although the standard drug (acarbose)
had the least half-maximal inhibitory concentration (IC50) value. Analytical and computational analysis iden-
tified the potential of cubenol, to interact with important residues of a-glucosidase and a-amylase emphasiz-
ing its hypoglycemic potential. The result of this study revealed that S. cordatum is a rich source of
pharmacologically important bioactive compounds with a remarkable capacity to retard a-amylase and
a-glucosidase enzymes. Cubenol was identified as an efficient and safe hypoglycemic agent of S. cordatum. |
| format | Article |
| id | 123456789-833 |
| institution | Asian University for Women |
| language | English |
| publishDate | 2025 |
| publisher | ELSEVIER |
| record_format | dspace |
| spelling | 123456789-8332026-02-18T06:15:22Z South African Journal of Botany Roy, Ayan Hyperglycemia a-glucosidase a-amylase Molecular docking Syzygium Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic dysfunction characterized by hyperglycemia. T2DM is a growing global epidemic with diffuse complications, including a high mortality rate. High blood sugar can be lowered by impeding the activities of pancreatic a-amylase and intestinal a-glucosidase enzymes. Although there are a number of orthodox medications used in the management of hyperglycemia, medicinal plants remain a veritable option in many cultures of the world owing to their overall efficacy and affordabil- ity. This study was designed to investigate the hypoglycemic potential of Syzygium cordatum leaf extract frac- tions in the retardation of pancreatic a-amylase and intestinal a-glucosidase enzymes in vitro. The bioactive components of the active fractions were identified using the Gas Chromatography-Mass Spectrometry (GC- MS) and their potential hypoglycemic properties were assessed using the molecular in silico modelling approach. The in vitro a-amylase and a-glucosidase inhibitory activities of S. cordatum revealed that the organic solvent fractions retarded the digestive enzymes considerably although the standard drug (acarbose) had the least half-maximal inhibitory concentration (IC50) value. Analytical and computational analysis iden- tified the potential of cubenol, to interact with important residues of a-glucosidase and a-amylase emphasiz- ing its hypoglycemic potential. The result of this study revealed that S. cordatum is a rich source of pharmacologically important bioactive compounds with a remarkable capacity to retard a-amylase and a-glucosidase enzymes. Cubenol was identified as an efficient and safe hypoglycemic agent of S. cordatum. 2025-07-30T03:43:48Z 2025-07-30T03:43:48Z 2024 Article https://repository.auw.edu.bd/handle/123456789/833 en application/pdf ELSEVIER |
| spellingShingle | Hyperglycemia a-glucosidase a-amylase Molecular docking Syzygium Roy, Ayan South African Journal of Botany |
| title | South African Journal of Botany |
| title_full | South African Journal of Botany |
| title_fullStr | South African Journal of Botany |
| title_full_unstemmed | South African Journal of Botany |
| title_short | South African Journal of Botany |
| title_sort | south african journal of botany |
| topic | Hyperglycemia a-glucosidase a-amylase Molecular docking Syzygium |
| url | https://repository.auw.edu.bd/handle/123456789/833 |
| work_keys_str_mv | AT royayan southafricanjournalofbotany |