| Shrnutí: | The first influenza pandemic in the 21st century commenced in March, 2009 causing nearly 300,000
deaths globally within the first year of the pandemic. In late 2013 and in early 2014, there was gradual
increase in the reported case of H1N1 infection and according to World Health Organization (WHO)
report, influenza activity increased in several areas of the Southern Hemisphere and was dominated by
the H1N1 pandemic strain of 2009. In the present study, a comprehensive comparison of the global amino
acid composition and the structural features of all HA gene sequences of H1N1, available in the Flu
Database (NCBI), from 1918 to December, 2014 has been performed to trace out the possibility of a
further H1N1 pandemic in near future. The results suggest that the increased potential to enhance
pathogenicity for the H1N1 samples of 2013 (latter part) and 2014 could lead to a more severe outbreak
in the near future.
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