| Tóm tắt: | The present study was performed to investigate the probable
analgesic and neuropharmacological activities of the ethyl acetate extract of
Ipomoea pes-tigridisLinn. We designed our study to search new analgesic
drug from plants which may be harmless to humans as available drugs for
the management of pains, fever have many known adverse effects. In
phytochemical screening, it was also found the presence of flavonoids,
glycosides, alkaloids, saponins, carbohydrates and tannins which have been
reported to be responsible for the analgesic activity in many studies. In
addition, comprehensive studies have not been performed yet to justify
potential CNS responses of the selected plant. In analgesic studies, the
extract of Ipomoea pes-tigridis showed significant analgesic activity(p<
0.05-0.000)both acetic acid induced writhing test and hot plate method in
mice. In acetic acid induced writhing model, the extract showed 16.5 6% and
33.125% of inhibition of writhing response at 100mg/kg and 200mg/kg
respectively. 100mg/kg dose exhibit maximum nociception inhibition at 30
min and 200 mg/kg exhibit highest nociception inhibition also at 30 min. 200
mg/kg extract exhibit basal reaction time 14 and 100 mg/kg extract exhibit
basal reaction time 13.8, ,where the positive control shows basal reaction
time 12.8 at 30 min. In case of neuropharmacological effect, the extract
didn’t display any significant dose dependent depression of motor activity as well as exploratory behavior in both hole cross method and open field test.
The results of this present study suggest that the extract possesses analgesic
effect but it doesn’t have any CNS depressant activities. The plant extract
might contain CNS stimuli effect and further investigation is required for the
confirmation.
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